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The mechanism of action by which the pseudocatalase
and calcium combination cream is believed to occur lies in the removal
of high levels of epidermal hydrogen peroxide, thereby stabilizing the
depigmentation phase of the disorder and initiating the repigmentation
of the skin.3
Clinical studies conducted worldwide
are holding great promise, as their results are only positive ones.
Take for instance, a study consisting of thirty-three patients living
with vitiligo who were treated with a topical application of
pseudocatalase, calcium, and a short-term exposure to UVB light. It was
found that the first sign of repigmention occurred as early as 2 to 4
months after the initiation of therapy and complete repigmentation on
the face and hands of patients was seen in 90% of the group. It was
also noted that no patients developed new lesions while on the therapy.5
In another similar study involving fifty-nine patients who were treated
for 21 days with the combination treatment of Dead Sea climatotherapy
plus pseudocatalase cream (PC-KUS), it was discovered that only after 15
minutes of Dead Sea bathing, there was a significantly higher decrease
of epidermal hydrogen peroxide compared to the use of narrow-band UVB
along with the pseudocatalase cream. It was observed that between days
10 and 16 after initiation of therapy that patients already regained the
beginning stages of repigmentation compared to the 2 to 4 months
discussed earlier. As a result, this study concluded that this combined
therapy produced a significantly faster response in repigmentation of
patient’s skin than the use of pseudocatalase, calcium, and UVB
treatment alone. The study supported the idea that not only is it
important to remove epidermal hydrogen peroxide, but also for a
successful treatment against vitiligo, solar UV-light is of equal
importance.6
At the moment, the mainstream treatment
against this discolorating disorder has no side effects, even
maintaining the affected patient’s normal liver function.4
As you can
see, the road in the treatment for vitiligo looks promising as more and
more knowledge about the disorder is being discovered, thus allowing
doctors and pharmacists all around the world to develop future
therapies. |
